The serotoninergic receptor subtype 5-HTR1B contributes to the pathogenesis of allergic airway inflammation

Introduction: In addition to its well described role in the nervous and cardiovascular system 5-hydroxytryptamine (5-HT, serotonin), has also potent immuno-regulatory properties. Furthermore, elevated levels of free serotonin have been detected in the serum of symptomatic asthmatics. However, the exact serotoninergic receptor subtypes involved have not been elucidated, yet. In this study we questioned whether the subtype 5-HTR1B is involved in the pathogenesis of experimental asthma. Methods: Expression of 5-HTR1B receptors in lung tissue was analyzed by immunohistochemistry. Allergic airway inflammation was stu…