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Invariant natural killer T (iNKT) cells regulate function of IL-10 producing monocytes in sarcoidosis

A Crawshaw, Y Kendrick, LP Ho · Pneumologie · 2012 · Heft 11

Dokument
1141798
CareLit-ID
Jahr
2012
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
A Crawshaw, Y Kendrick, LP Ho
Ausgabe
Heft 11 / 2012
Seiten
–
Erschienen: 2012-11-13 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0032-1329828

Zusammenfassung

Marked TH1-biased CD4 T cell activity dominates the acute phase of sarcoidosis, potentially contributing to formation and persistence of granuloma. The cause of this abnormal process is unclear. We have observed a reduction in iNKT cells in this condition (Ho et al Lancet 2005) and shown that iNKT cells influenced the function of monocytes in inflammatory conditions (Kok et al JLB 2011, Denney et al JI 2012). Here, we questioned if iNKT cells may be involved in controlling T cell activity via their interaction with monocytes. We first show that iNKT cells are able to increase IL-10 production from human monocyte…

Schlagworte

Cells Monocytes Il-10 These Sarcoidosis Proliferation Activity Process Reduction Production Suppress Co-Culture Pneumologie