Hepatic accumulation of IL-17 producing γδ T cells via chemokine receptor CCR6 restricts liver inflammation and fibrosis by inhibiting hepatic stellate cells
L Hammerich, F Heymann, HW Zimmermann, JM Bangen, N Gaßler, S Huss, C Liedtke, I Prinz, SA Lira, T Luedde, C Trautwein, F Tacke · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aim: The chemokine receptor CCR6 is known to be expressed on some T helper cells and γδ T cells, monocyte derived dendritic cells and B cell subsets. It plays an important role in mucosal immunity, but its role in liver disease is largely unknown. In this study we investigated its functional relevance in chronic liver disease and hepatic fibrosis. Methods: Liver inflammation and fibrosis was induced in wildtype (wt) and Ccr6-/- mice by carbon tetrachloride (CCl4) thrice weekly over 4 weeks. Immune cell subsets were isolated from livers by FACS sorting and co-cultured with stellate cells. Human liver samples from…
