Hepatic Stellate Cells-derived JNK1 is a crucial mediator
FJ Cubero, G Zhao, M Hatting, YA Nevzorova, MV Boekschoten, O Drvarov, T Roskams, M Müller, RJ Davis, C Trautwein · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background and Aim: Hepatic fibrosis is a wound-healing response to chronic liver injury, which frequently results in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (Jnk1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved in mediating the Jnk1-dependent effect on liver fibrogenesis. Methods: Wild-type (WT), Jnk1–/– and Jnk1Δhepa (hepatocyte-specific deletion of JNK1) mice were subjected to (i) bile duct ligation (BDL) and (ii) CCl4- induced liver fibrosis. Additionally, we performed bone marrow transplantati…
