CareLit Fachartikel
Bone marrow transplantation (BM-Tx) of CD117+ cells in Abcb4 knockout mice
S Pasupuleti, M Roderfeld, E Roeb · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Dokument
1141893
CareLit-ID
Jahr
2013
Publikation
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Metadaten
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Zusammenfassung
Introduction: We demonstrated positive effects of bone marrow transplantation (BM-Tx) on the long term which were attributed to enhanced fibrolysis in consequence of graft-versus-host induced Th2→Th1 shift (1). In the follow up study we intended to avoid graft versus host effects and focused on reconstitution of Abcb4-transporter function in recipient's hepatocytes by fusion with Abcb4+ transplanted hematopoietic stem cells (2). With the present study we analyzed regenerative potential of transplantation of desialylated and sorted CD117+ hematopoietic stem cells in Abcb4-/- mice, a model of cholangitis. Methods:…
Schlagworte
Dendritic Cells
Transplantation
After
Cholangitis
Cytokines
Zeitschrift für Gastroenterologie
