The novel endocannabinoid noladin ether holds putative anti-fibrotic properties by selectively inducing cell death in hepatic stellate cells
M Schlosser, A Wojtalla, FA Schildberg, PA Knolle, MV Singer, T Sauerbruch, A Zimmer, SV Siegmund · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: We could previously demonstrate that the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG) is an antifibrotic lipid mediator that blocks proliferation and induces apoptotic cell death in hepatic stellate cells (HSCs), but not in hepatocytes. Recently a novel endocannabinoid termed noladin ether (NE, 2-arachidonyl glyceryl ether) has been identified, which represents a more stable entity against enzymatic hydrolysis than 2-AG. Aims: To test the effects of NE on hepatic cell populations. Methods: Primary hepatocytes and HSCs were isolated from healthy rat or mouse liver by collagenase perfusion. Ce…
