miR-198 controls migration in hepatocellular carcinoma by regulation of Claudin 1
N Elfimova, A Noetel, M Kwiecinski, D Becker, P Nürnberg, A Teufel, HP Dienes, U Drebber, M Odenthal · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer deaths, worldwide. MicroRNAs, inhibiting gene expression by targeting various transcripts, are involved in genomic dysregulation during hepatocellular tumorigenesis. In previous studies, microRNA-198 (miR-198) was shown to be significantly downregulated in HCV-positive hepatocellular carcinoma (HCC). Herein, the function of miR-198 in hepatocellular carcinoma cell growth and gene expression was studied. Methodology: The miR-198 expression level and the transcription levels of the liver-specific transcription factors HNF1α and HNF4α…
