Nuclear proteins in primary biliary cirrhosis as guardians against HCC development
C Hintemann, K Straub, S Biesterfeld, PR Galle, J Erthle, G Gerken, A Canbay, K Herzer · Zeitschrift für Gastroenterologie · 2013 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Primary biliary cirrhosis (PBC) is an autoimmune disorder of the liver which is characterised by an aseptic inflammation, accompanied by destruction of cholangiocytes of the small bile ducts. The subgroup M2 of antimitochondrial antibodies (AMA-M2) is considered as specific for the disease. In addition, there is evidence in about 30% of patients to express antibodies against certain nuclear-dot proteins (Anti-ND), SP100- and promyelocytic leucemia (PML) – protein. However, implications of the respective antigenes, PML- and SP100-protein, for pathogenesis and course of PBC have not yet been further in…
