CareLit Fachartikel

Opposite role for the chemokines CCL5 (RANTES) and CXCL3 (IP-10) in the development of autoimmune liver disease in the CYP2D6 mouse model

J Ehser, E Hintermann, M Bayer, J Pfeilschifter, U Christen · Zeitschrift für Gastroenterologie · 2013 · Heft 01

Dokument
1141912
CareLit-ID
Jahr
2013
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
J Ehser, E Hintermann, M Bayer, J Pfeilschifter, U Christen
Ausgabe
Heft 01 / 2013
Seiten
–
Erschienen: 2013-01-11 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0032-1332128

Zusammenfassung

The etiology of autoimmune hepatitis (AIH) is poorly understood although the major autoantigen, cytochrome P450 2D6 (CYP2D6), has been identified and immunodominant epitopes mapped. We generated a mouse model for AIH using the natural human autoantigen CYP2D6 as a triggering molecule. Wildtype C57BL/6 mice are infected with an adenovirus expressing the human CYP2D6 (Ad-2D6) in order to break self-tolerance to the mouse CYP2D6 homologues (molecular mimicry). Such mice display persistent features characteristic for liver damage associated with AIH (fibrosis, 'fused' lobules, cellular infiltrations and necrosis). A…

Schlagworte

Chemokines Autoimmune Hepatitis Hepatitis Antibodies Cytochrome After Zeitschrift für Gastroenterologie