CareLit Fachartikel

Cholestasis correlates with higher DPPIV activity and higher IP-10 serum levels in patients with chronic hepatitis C

M Rau, J Schmitt, P Frei, K Spanaus, B Müllhaupt, A Geier · Zeitschrift für Gastroenterologie · 2013 · Heft 01

Dokument
1141916
CareLit-ID
Jahr
2013
Publikation
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Rau, J Schmitt, P Frei, K Spanaus, B Müllhaupt, A Geier
Ausgabe
Heft 01 / 2013
Seiten
–
Erschienen: 2013-01-11 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0032-1332168

Zusammenfassung

Background: A significant proportion of end stage liver disease is caused by chronic hepatitis C (HCV) infection. Studies have shown that high baseline interferon-gamma-inducible protein-10 (IP-10) concentration correlates with nonresponse to peginterferon/ribavirin therapy and with first and second phase viral kinetics in patients with chronic hepatitis C infection. IP-10 serum concentrations are good surragete parameters for intrahepatic induction of interferon stimulated gene (ISG) activation. Recently higher IP-10 serum concentrations were described as antagonist forms of IP-10 cleaved by DPPIV (Casrouge et…

Schlagworte

Cholestasis Hepatitis Biopsy Zeitschrift für Gastroenterologie