CareLit Fachartikel

The role of ATP and purinergic-receptor-signalling in the pathogenesis of ALI/ARDS

S Cicko, T Müller, K Ayata, A Zech, K Baudiß, M Grimm, A Meyer, M Braun, S Sorichter, M Idzko · Pneumologie · 2013 · Heft 02

Dokument
1142026
CareLit-ID
Jahr
2013
Publikation
PDF
nein
Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
S Cicko, T Müller, K Ayata, A Zech, K Baudiß, M Grimm, A Meyer, M Braun, S Sorichter, M Idzko
Ausgabe
Heft 02 / 2013
Seiten
–
Erschienen: 2013-02-27 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0033-1334718

Zusammenfassung

Background: Extracellular ATP serves as a danger signal to alert the immune system after tissue damage by acting on P2X or P2Y receptors. Acute lung injury (ALI)/acute respiratory syndrome (ARDS) is characterized by rapid alveolar injury, inflammation, cytokine production, neutrophils accumulation and vascular leakage leading to lung oedema. While recent data point out to an important role of ATP/P2R-axis in chronic inflammatory lung diseases such as asthma and COPD, its role in ALI/ARDS is unknown. Aims: To investigate the role of ATP and purinergic-receptor-signalling in the pathogenesis of ALI/ARDS. Methods a…

Schlagworte

Acute Lung Injury Cytokines Apyrase Axis After Cytokine Address Asthma Pneumologie