CareLit Fachartikel
Investigations into the bioactive constituents of hawthorn extract WS® 1442 responsible for its endothelial barrier protecting activity
S Fuchs, EA Willer, E Hartung, AM Vollmar, O Potterat, M Hamburger, R Fürst · Zeitschrift für Phytotherapie · 2013 · Heft 03
Dokument
1142150
CareLit-ID
Jahr
2013
Publikation
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Zusammenfassung
We could previously prove that WS® 1442, a herbal drug approved against mild forms of heart failure, efficiently prevents inflammation-induced endothelial hyperpermeability in vitro and in vivo by blocking the Ca2+/PKC/RhoA pathway and by activating cAMP/Rap1/Rac1 signaling [1]. In the search for the constituents responsible for these effects, we previously examined 4 different fractions (A-D) of WS® 1442 (Sephadex LH-20 column chromatography, kindly provided by Dr. Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany) and found that only fraction B (small phenolic compounds, flavonoids, and lipophilic components)…
Schlagworte
Calcium
Calcium Signaling
Chromatography
Cortactin
Germany
Zeitschrift für Phytotherapie
