Influence of exercise training on eNOS amount and phosphorylation in skeletal muscle of non-insulin dependent typ-2-diabetic men

Diabetes has been shown to go along with the development of hypertension and myocardial infarction. The pathophysiological link between the different diseases is a dysregulation of the vascular endothelial nitric oxide synthase (eNOS), an endothelial enzyme which induces vasodilation by the release of nitric oxide (NO) after being itself phosphorylated at serine 1177. Physical activity has been shown to improve eNOS protein expression and regulation by serine 1177. Less is known on eNOS-physiology and regulation in skeletal muscle, its alterations in diabetic persons and whether physical activity may influence s…