Selective inhibition of chemokine CCL2/MCP-1 reduces experimental pulmonary hypertension
D Kosanovic, BK Dahal, C Vroom, E Bieniek, H Ardeschir Ghofrani, N Weissmann, W Seeger, F Grimminger, S Klussmann, D Eulberg, RT Schermuly · Pneumologie · 2013 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: It has been shown previously that the increased levels of pro-inflammatory infiltrates and accumulation of inflammatory cells are present in clinical and experimental pulmonary hypertension (PH), suggesting the role of inflammation in pulmonary vascular remodelling. Literature implicates the involvement of the chemokine CCL2/monocyte chemoattractant protein (MCP)-1 in PH development. This study aimed to investigate if the selective inhibition of MCP-1 by the Spiegelmer mNOX-E36 had therapeutic potential in animal models of PH, such as monocrotaline injection in rats (MCT-rats) and chronic hypoxia exp…
