Time-dependent changes in inflammatory markers in a rat model of colitis by leisure sport activity

Introduction: A regular exercise has a beneficial effect on chronic inflammatory disorders, but little is known about the influence of exercise on inflammatory bowel disease. Methods: After 3, 6 and 10 weeks self-administered exercise (running wheel) male Wistar rats were treated with TNBS (10 mg) to induce colitis. Groups are: absolute control, running control, non-running TNBS and running TNBS-treated. 72h after TNBS treatment colon samples were collected to measure inflammatory parameters (3/6/10 weeks), myeloperoxidase (MPO, 6/10 weeks), heme-oxygenase (HO) and nitric-oxide-synthase (NOS) activities (6 weeks…