eNOSI4 and EPHX1 polymorphisms affect maternal susceptibility to preeclampsia – analysis of five polymorphisms predisposing to cardiovascular disease in 279 Caucasian and 241 Afri…

Objectives: With an incidence of 3 – 7% in all pregnant women preeclampsia is still the leading cause of fetal and maternal mortality. Clinical studies have documented a familiar tendency to develop preeclampsia. Additionally, patients with impaired endothelial health are at increased risk. We studied genetic polymorphisms associated to cardiovascular disease and impaired endothelial function in women with and without preeclampsia. Methods: 241 African and 279 Caucasian women were recruited in a two hospital-based case-control study for genetic testing of the polymorphisms epoxide hydrolase 1 (EPXH1) (Tyr113His)…