CareLit Fachartikel
The herbal preparation, STW 5, protects against radiation induced intestinal mucositis
MT Khayyal, MA El-Ghazaly, DH Abdel-Naby, D Weiser, H Abdel-Aziz · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Dokument
1142744
CareLit-ID
Jahr
2013
Publikation
PDF
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Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Intestinal mucositis is a common adverse effect in cancer patients undergoing radiotherapy and is associated with apoptotic processes. The condition has been simulated in rats by exposing them to acute radiation from a Cesium 137 source. The extent of intestinal injury was dependent on the radiation dose level and histological evidence of apoptosis was shown at an exposure of 8 Gray. Apoptotic changes were associated with a marked increase in cytosolic calcium, depletion of mitochondrial cytochrome c, B-cell lymphoma-2 and complex 1. Serum diamine oxidase and lactate dehydrogenase as well as intestinal tumor nec…
Schlagworte
Cytochrome C
Cytochrome
Apoptosis
Calcium
Diamine
Germany
Cesium
After
Tumor
Zeitschrift für Gastroenterologie
