Bcl-3 protects acute pancreatitis by stabilizing p50 homodimers
S Liang, P Neuhöfer, A Jiaoyu, M Lesina, M Treiber, N Diakopoulos, K Dlubatz, M Riemann, S Wörmann, RM Schmid, H Algül · Zeitschrift für Gastroenterologie · 2013 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: The IKK/NF-kappaB pathway is activated very early in acute pancreatitis (AP). The role of specific subunits of this pathway in AP however remains unclear so far. In particular, the role of the atypical Bcl-3 protein which resides predominantly in the nucleus and is not degraded upon NF-kappaB activation has not been addressed. Material and methods: Using Bcl-3 deficient mice (Bcl3–/– ), local damage and the systemic complications of AP were analyzed. Bone marrow transplantation experiments of Bcl3–/– and control mice were performed to scrutinize the role of Bcl-3 in vivo. Results: Our data showed t…
