Targeting differentially expressed histone deacetylases in Medulloblastoma – novel approach for treatment of high risk patients
J Ecker, I Oehme, A Schomburg, R Mazitschek, A Korshunov, M Kool, M Lodrini, HE Deubzer, A von Deimling, AE Kulozik, S Pfister, O Witt, T Milde · Klinische Pädiatrie · 2013 · Heft 11
Bibliografische Angaben
Zusammenfassung
Introduction: Medulloblastoma (MB) is the most common malignant brain tumor in children. According to the current consensus MB comprises 4 different molecular subgroups with highly variable clinical courses. In particular patients with Group 3 tumors show poor overall survival despite multimodal treatment, and novel treatment strategies are urgently needed. Histone deacetylase (HDAC) expression levels are frequently dysregulated in MB. We here explore the potential of isoenzyme-selective HDAC inhibition as an innovative approach for treatment of MB. Methods: Expression of HDACs in MB was compared to normal brain…
