Sinusoidal obstruction syndrome (SOS) and nodular liver regenerates (NRH): Tracking FOLFOX liver injury with CEUS

Purpose: In a challenging case of 5 new focal liver lesions in a patient 6 years after colon carcinoma characterization by follow-up CEUS was supplemented by detailed histopathological workup. Material and methods: 46-year old patient, colon carcinoma 6 years ago (pT3pN1cM0G3). Postoperatively due to high-risk situation (N1) and young age yearly ultrasound examinations including CEUS were performed. 6 years after an adjuvant oxaliplatin-based chemotherapy (FOLFOX4) 5 new hypervascularized focal liver lesions of 3 – 8 mm were detected by B-mode US and CEUS, 2 of them intraoperatively. One lesion showed a wash-out…