Programmed liver biopsies after orthotopic liver transplantation predict non-alcoholic steatohepatitis during a 5-year follow up
M Petri, E Müller, A Schad, M Hoppe-Lotichius, S Koch, J Schattenberg, T Zimmermann, J Mittler, H Lang, PR Galle, A Weinmann, MF Sprinzl · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Metabolic deterioration after orthotopic liver transplantation (OLT) may affect hepatic pathology and outcome. Following a previous study which identified incipient non-alcoholic liver disease (NAFLD) in context of a post OLT metabolic syndrome (1), we investigated whether early histologic changes are predictive for occurrence of steatohepatitis (NASH) during long-term follow up. Material and Methods: Patients (N = 144) receiving OLT between 1998 and 2007 at a single transplant center were retrospectively analyzed over a period of 5 years post OLT. OLT with a complete clinical history and a programme…
