Deficiency of group via Phospholipase A2 in OB/OB mice renders protection against hepatic steatosis by reduction of VLDL secretion and alteration of phospholipid fatty acid compos…

Introduction: iPLA2β hydrolyzes fatty acyl bond at the sn-2 position of phospholipids (PL) recognized as a key process on homeostatic membrane metabolism. iPLA2β and its product lysophospholipids play a role in lipid synthesis and very low density lipoprotein (VLDL) assembly. Our previous study shows that global whole body deficiency of iPLA2β causes lower body weight as well as lower serum and hepatic lipids when compared with the control littermates (WT). Aims: We herein tested whether global deficiency of iPLA2β would attenuate adiposity and hepatic steatosis in leptin-knockout Ob/Ob (OB) mice. Methods: We pe…