Stabilization of protumorigenic FUSE binding proteins (FBPs) in hepatocarcinogenesis
J Samarin, I Stein, E Horwitz, C Ho, X Chen, E Pikarsky, D Calvisi, P Schirmacher, K Breuhahn · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Far upstream element-binding proteins (FBPs) represent a family of transcription factors, which are highly overexpressed in the majority human hepatocellular carcinoma (HCC). Nuclear FBP accumulation in HCC cells support tumor cell proliferation (FBP-1/-3) and migration (FBP-3). Although, FBPs are promising therapeutic target structures, the underlying mode of dysregulation has not been defined so far. Methods: Genomic alterations of the fubp (FBP-1; chr. 1p31.1), khsrp (FBP-2; chr. 19.p13.3), and fubp3 (FBP-3; 9p34.11) gene loci in primary human HCCs were determined by matrix-CGH. In order to identi…
