Immunotherapeutic retargeting of effector cells towards HBV infected target cells using bispecific antibody constructs
F Bohne, C Meyer, O Quitt, A Dhamodaran, L Alvarez, S Caballero, A Guillamet, V Bruss, G Moldenhauer, F Momburg, U Protzer · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Retargeting of effector cells is a promising immune-therapeutic approach to circumvent the immunotolerant state found in malignancies and chronic viral infections. Effector cells are supplied with designed specificities allowing redirection, and can be further equipped with costimulatory signals, together reverting the immunocompromised situation. To achieve retargeting against HBV-infected cells, we constructed tetravalent bispecific antibody constructs harboring two different binding moieties of immunoglobulins. The first binding site had been designed to target HBV-infected cells by binding the S domain of HB…
