Maternal Liver Damage Programs Offspring Allergic Inflammation in Mice
K Karimi, T Kessler, K Ramisch, E Tasika, P Arck, G Tiegs · Zeitschrift für Gastroenterologie · 2014 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: Liver disease can occur in the pregnant patient and pregnancy may occur in a patient with chronic liver disease, which in both cases severe consequences in the mother and fetus are expected. Prenatal risk factors may affect the development of allergies and human studies provided considerable indications for a correlation between the use of Acetaminophen (APAP) and an increased risk of the children to develop allergies. APAP is mainly metabolized in the liver, and freely crosses the placenta, resulting in pharmacologically active levels in the developing fetus. In the fetus, the liver transiently fu…