Reactive oxygen species delay control of lymphocytic choriomeningitis virus

CD8+ T cells are of critical importance to prevent chronic viral infections because they not only promote virus elimination, but also induce virus mediated immunopathology. Elevated levels of reactive oxygen species (ROS) have been reported during virus infections. However, the role of ROS in T cell mediated immunopathology remains unclear. Here we used the murine lymphocytic choriomeningitis virus to explore the role of ROS during the processes of virus elimination and induction of immunopathology. We found that virus infection led to elevated levels of ROS producing granulocytes and macrophages in virus infect…