CareLit Fachartikel
The TGF-ß antagonist Bambi impacts the expression of pro-inflammatory cytokines in a mouse model of allergic bronchial asthma
C Vock, M Wegmann, H Fehrenbach · Pneumologie · 2014 · Heft 02
Dokument
1143444
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Jahr
2014
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Zusammenfassung
Introduction: Allergic bronchial asthma is characterized by chronic inflammatory processes and airway remodeling, which are linked to airway hyperresponsiveness (AHR) and impaired lung function. The Transforming Growth Factor beta (TGF-ß) is an important factor dampening inflammatory processes, but with persistence of pro-inflammatory processes also mediates structural changes of the airways. Bambi (Bone Morphogenetic Protein and Activin Membrane-bound Inhibitor) was described to act as TGF-ß type I pseudoreceptor that lacks the intracellular kinase domain and inhibits TGF-ß-dependent signaling. Objective: The c…
Schlagworte
Asthma
Cytokines
Airway Remodeling
Cytokine
Activin
Pneumologie
