Insulin stimulates FoxO4 protein abundance in human skeletal muscle in lean healthy but not in obese subjects with or without type 2 diabetes

Fragestellung: Many studies show negative impact of inflammation-mediating molecules like Tumor necrose factor α (TNFα) or Interleukin-6 (IL6) on insulin signaling in skeletal muscle (Plomgaard et al. 2005, Guilherme et al. 2008). Conversely, only few studies have investigated the effect of insulin on generation of these cytokines (Krogh-Madsen et al. 2003, Plomgaard et al. 2007). Here we hypothesize that increased abundance of the transcription factor FoxO4 may play a role in cytokine-mediated perturbation of insulin signaling. Methodik: Skeletal muscle biopsies were obtained under basal and euglycemic hyperins…