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Nicotinamide N-methyltransferase is a novel regulator of energy metabolism in adipose tissue

D Kraus, Q Yang, D Kong, AS Banks, L Zhang, JT Rodgers, E Pirinen, TC Pulinilkunnil, F Gong, YC Wang, Y Cen, AA Sauve, JM Asara, OD Peroni, BP Monia, S Bhanot, L Alhonen, P Puigserver, BB Kahn · Diabetologie und Stoffwechsel · 2014 · Heft 05

Dokument
1143840
CareLit-ID
Jahr
2014
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Diabetologie und Stoffwechsel
Autor:innen
D Kraus, Q Yang, D Kong, AS Banks, L Zhang, JT Rodgers, E Pirinen, TC Pulinilkunnil, F Gong, YC Wang, Y Cen, AA Sauve, JM Asara, OD Peroni, BP Monia, S Bhanot, L Alhonen, P Puigserver, BB Kahn
Ausgabe
Heft 05 / 2014
Seiten
–
Erschienen: 2014-05-06 00:00:00
ISSN
1861-9002
DOI
10.1055/s-0034-1374908

Zusammenfassung

Objective: To investigate the role of nicotinamide N-methyltransferase (NNMT) in the regulation of energy metabolism. Methods: DNA arrays of genetically engineered insulin-sensitive and insulin-resistant mice were screened for reciprocally regulated genes. NNMT expression was studied in obese and insulin-resistant mouse models. Knockdown of NNMT was achieved in adipose tissue of high-fat diet-induced obese (HFD) mice using antisense oligonucleotides. Results: NNMT is strongly and reciprocally regulated in insulin-sensitive and insulin-resistant mice. NNMT expression is increased in adipose tissue of several obes…

Schlagworte

Adipocytes Obesity Diet Diabetologie und Stoffwechsel