Novel diabetes QTL on chromosomes 1, 9, 11 and 13 identified in an NZOxC57BL/6J backcross population
A Kamitz, N Hallahan, R Burkhardt, G Schulze, M Jähnert, R Kluge, W Jonas, HG Joost, A Schürmann · Diabetologie und Stoffwechsel · 2014 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: The New Zealand Obese (NZO) mouse is a model for human polygenic obesity and type 2 diabetes. Outcross experiments with lean strains led to the discovery of various quantitative trait loci (QTL) and the subsequent identification of diabetes and obesity genes by positional cloning. The aim was to identify novel diabetes genes and suppressors in a backcross population of the NZO with the diabetes resistant C57/BL6J (B6) mouse. Methods: The phenotype of 600 mice of the backcross population on high-fat diet (45% fat) was monitored (body weight, blood glucose, insulin sensitivity, body composition). Furth…
