Severe hypoglycaemia under therapy with sulfonylurea in patients with type 2 diabetes (T2D) in Germany/Austria: Event rate and identification of patients at risk

Background: We investigated the rate of severe hypoglycemia and confounding factors in T2D patients treated with sulfonylurea (SU) in the German/Austrian DPV-Wiss-database cohort. Methods: Data from 29,485 SU-treated patients were analyzed (mean (SD) age 69.5 (11.5)yrs, diabetes duration 9.7 (7.6)yrs, with/without antidiabetic co-medication). Primary objective was to estimate the event rate of severe hypoglycemia (defined as requirement for help +/-coma or emergency hospitalization due to hypoglycemia). Secondary objective was the identification of confounding risk factors for hypoglycemia through group comparis…