The GLP-1 metabolite (9 – 37) improves myocardial function in the TAC model by reducing myocardial hypertrophy and improving glucose uptake

Purpose: Diastolic dysfunction and myocardial hypertrophy are signs of hypertensive cardiomyopathy. GLP-1(7 – 37) is an incretin hormone which is released in response to nutritional stimuli from the gut and improves glucose metabolism by increasing glucose dependent insulin secretion from the pancreas. GLP-1(7 – 37) is rapidly cleaved to its inactive metabolite GLP-1(9 – 37) which can't bind to the GLP-1 receptor and doesn't cause insulin secretion. Nevertheless both peptides have been found to hold cardioprotective actions. Methods and Results: To investigate the effects of GLP-1 on hypertensive cardiomyopathy…