hiPSC derived endothelial cell types from scalable cultures for biofunctionalization and tissue engineering

Applications like full endothelialisation of gas exchange membranes in extracorporal membrane oxygenation (ECMO) devices for improved hematocompatibility, cell therapy of pulmonary hypertrophy or tissue engineering require large numbers of (patient-specific) endothelial cells (ECs). The isolation of ECs from peripheral blood or explanted vessels is well established however especially cells from older individuals show a limited proliferation capacity. Patient specific ECs from pluripotent stem cells (hiPSCs) might be an alternative suitable cell source. The opportunity to generate large amounts of undifferentiate…