Improved efficacy of temoporfin photodynamic therapy in locally advanced biliary tract carcinoma: a multicenter prospective phase II study
A Wagner, UW Denzer, D Neureiter, T Kiesslich, F Berr, A Puspoeck, K Emmanuel, AW Lohse, U Beuers, EA Rauws, N Degenhardt, GW Wolkersdörfer · Zeitschrift für Gastroenterologie · 2014 · Heft 08
Bibliografische Angaben
Zusammenfassung
Introduction: Photodynamic therapy using porfimer (P-PDT) is established local tumor ablative therapy in non-resectable hilar bile duct cancer (hBDC) improving palliation and survival time. Tumoricidal penetration depth is only 4 mm with P-PDT, but at least 8 mm with temoporfin PDT (T-PDT). Aim: Therefore, we investigated in a single-arm phase II study (NCT01016002; from 2005 to 2011) non-inferiority of T-PDT vs. previous P-PDT in OS, local tumor control (TTP), and adverse events (ADE). Material and Patients: Patients (n = 29) with unresectable hBDC received median 1.0 (range 1 – 4) T-PDT plus stenting and were…
