Does the genetic strain influence severity of acute necrotizing pancreatitis and SIRS in a murine model?

Background: To date, it remains unclear which impact the genetic background has on the severity of acute pancreatitis concerning local and systemic parameters. Aim: To evaluate the impact of genetic background on the severity of acute necrotizing pancreatitis and systemic inflammatory response in mice. Materials and methods: We examined 9 strains of male mice: Balb/CB4J, C3 H/HEJ, NOD/SHILT, A/J, AKR/J, C57BI/6J, DBA/2J, FVB/NJ, 129S1/SVlm. 10 animals per strain were randomly allotted to even groups of 5 animals. Sterile necrotizing pancreatitis was induced by retrograde injection of 4% taurocholate in the commo…