Dual tocolysis with fenoterol and atosiban in human myometrium demonstrates additive effect in vitro

Introduction: A combination of tocolytic agents may be reasonable in order to expand therapeutic options. In vitro studies in rats have demonstrated that the combination of ritodrine with atosiban led to a synergistic inhibition of myometrial contractility. Currently there are no studies in human myometrium. Materials and methods: Human myometrial biopsies were obtained during elective caesarean sections of singleton pregnancies at term. Stripes were clamped in a myograph and regular spontaneous contractions were set as reference level. Samples were exposed to atosiban, fenoterol, atosiban plus fenoterol or Kreb…