CareLit Fachartikel

GPER is inactivated by promoter methylation and potentially functions as a tumor suppressor in breast cancer

C Weißenborn, T Ignatov, SD Costa, AC Zenclussen, A Ignatov · Geburtshilfe und Frauenheilkunde · 2014 · Heft 09

Dokument
1144258
CareLit-ID
Jahr
2014
Publikation
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Bibliografische Angaben

Zeitschrift
Geburtshilfe und Frauenheilkunde
Autor:innen
C Weißenborn, T Ignatov, SD Costa, AC Zenclussen, A Ignatov
Ausgabe
Heft 09 / 2014
Seiten
–
Erschienen: 2014-09-05 00:00:00
ISSN
0016-5751
DOI
10.1055/s-0034-1388378

Zusammenfassung

Purpose: More than 50% of breast cancer patients express high levels of membrane-bound G-protein coupled estrogen receptor (GPER) which is favorable for their survival. We investigated the role of GPER as potential tumor suppressor in breast cancer cells with special focus on triple-negative breast cancer (TNBC). Methods: After stimulation of breast cancer cell lines MCF-7, SK-BR-3 and TNBC cell lines MDA-MB-231 and MDA-MB-468 with specific GPER ligand G-1 we analyzed cell cycle distribution and apoptosis. Methylation status of the GPER promoter was investigated by methylation-specific PCR and 5-Aza-2'-deoxicyti…

Schlagworte

Breast Tumor After Apoptosis Caspase 3 Geburtshilfe und Frauenheilkunde