Molecular genetic analysis of thirty-five diffuse high-grade astrocytomas in children < 3 years of age defines a distinct infant HGG entity
GH Gielen, M Gessi, FR Buttarelli, C Baldi, J Hammes, A zur Muehlen, E Doerner, F Giangaspero, AO von Bueren, CM Kramm, A Waha, T Pietsch · Klinische Pädiatrie · 2014 · Heft 12
Bibliografische Angaben
Zusammenfassung
Pediatric high-grade gliomas (pHGG) are considered to differ from adult HGG in their pathogenesis and biological behaviour. However, few cases of infants have been analyzed so far. We studied the molecular features in a cohort of 35 infants with diffuse high-grade astrocytomas (8 anaplastic astrocytomas (WHO grade III) and 27 glioblastomas (WHO grade IV)) by immunohistochemistry, multiplex ligation probe-dependent amplification (MLPA), ALT-FISH, pyro-sequencing of glioma-associated genes and molecular inversion probe (MIP) assay. MIP and MLPA analysis showed that chromosomal alterations are significantly less fr…
