CareLit Fachartikel
Evaluation of the effect of genetic variation in the natural killer cell receptor on liver stiffness and survival in patients with chronic liver disease
F Grünhage, M Krawczyk, F Lammert · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1144739
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben
Zusammenfassung
Introduction: Recently the natural killer cell receptor G2D (NKG2D) has been shown to be involved in NK-cell induced apoptosis of hepatic stellate cells in chronic hepatitis C virus (HCV) infection. Given the critical role of stellate cells in the development of liver fibrosis we speculate that functional polymorphisms in this gene influence fibrosis progression or even survival of patients with advanced cirrhosis. Thus we studied the influence of a common NKG2D polymorphism that has also been associated to cholangiocarcinoma on liver stiffness and survival in two different cohorts of patients with liver disease…
Schlagworte
Association
Cholangiocarcinoma
Apoptosis
Alleles
Biopsy
Hepatitis
Zeitschrift für Gastroenterologie
