CareLit Fachartikel
The extracellular proteinase Expi/Wfdc18 in liver damage and tumour development: A new connection between inflammation, fibrogenesis and malignant growth
R Liebe, R Hall, E Burgermeister, M Ebert, F Lammert, S Dooley · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Dokument
1144742
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: Recently we have identified quantitative trait loci (QTLs) that determine susceptibility to TGF-beta signalling in mouse hepatocytes in vitro and fibrogenesis in vivo (Liebe et al. Physiol Genomics 2013). Expi/Wfdc18 candidacy was identified by eQTL and DNA variant analyses. Expi/Wfdc18 knockout animals showed decreased hepatic collagen contents following 6 weeks of CCl4 challenge. Methods: To assess the function of Expi outside its normal role in mammary gland development and antibacterial defence in salivary glands, we performed an in silico analyses of Expi/Wfdc18 expression and a systematic sea…
Schlagworte
Wfdc18
Fibrogenesis
Mouse
Liebe
Mammary
Tumours
Liver
Development
Malignant
Growth
Recently
Identified
Zeitschrift für Gastroenterologie
