Upregulation of Krüppel-Like Factor 6 is associated with acute liver injury in mice and humans
S Sydor, J Best, P Manka, M Schlattjan, T Schreiter, D Vetter, A Paul, SL Friedman, G Gerken, A Canbay, LP Bechmann · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: Krüppel-like factor 6 (KLF6) is a ubiquitously expressed, multifunctional transcription factor and tumor suppressor gene. In previous studies, we identified KLF6 as an important transcription factor in hepatocyte glucose and lipid homeostasis, and downregulation of KLF6 was associated with accelerated tumor-growth of hepatocellular cancer. So far, no data is available on the role of KLF6 in acute liver injury and regeneration. Here, we aimed to investigate the expression pattern of hepatocyte KLF6 in patients with acute liver failure (ALF), in a human ex-vivo perfusion model of acetaminophen induced…
