CareLit Fachartikel

Serum sterol levels indicate distorted cholesterol homeostasis in cirrhotic patients with primary biliary cirrhosis

M Krawczyk, E Wunsch, D Lütjohann, F Lammert, P Milkiewicz · Zeitschrift für Gastroenterologie · 2015 · Heft 01

Dokument
1144748
CareLit-ID
Jahr
2015
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
M Krawczyk, E Wunsch, D Lütjohann, F Lammert, P Milkiewicz
Ausgabe
Heft 01 / 2015
Seiten
–
Erschienen: 2015-01-16 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0034-1397148

Zusammenfassung

Background: In humans new cholesterol derives from de novo synthesis and intestinal absorption. Serum cholesterol precursor (e.g., lathosterol, desmosterol) and plant sterol levels (e.g., sitosterol, campesterol) represent valid surrogate marker for cholesterol biosynthesis and intestinal absorption, respectively. Since chronic liver diseases modulate cholesterol homeostasis, we systematically investigated sterol serum levels in patients with primary biliary cirrhosis (PBC) with and without liver cirrhosis. Patients and methods: Overall, we recruited 111 non-transplanted PBC patients (age 22 – 83 years, 101 fema…

Schlagworte

Cholesterol Absorption Desmosterol Chromatography Diagnosis Zeitschrift für Gastroenterologie