CareLit Fachartikel
Inducing active demethylation through 5-Azacytidine open a new aspect for treatment of Hepatocellular Carcinoma
SO Sajadian, S Ehnert, A Bachmann, B Sipos, AK Nuessler · Zeitschrift für Gastroenterologie · 2015 · Heft 01
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1144751
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Jahr
2015
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Zusammenfassung
Background: Hepatocellular carcinoma (HCC) is the fifth deadliest cancer worldwide. Global deregulation of the methylation status is one of the main causes of HCC. The oxidation of 5-methylcytosine (5mC) triggers the formation of 5-hydroxymethylcytosine (5hmC). 5hmC can be depleted from the genome through down-regulation of the TET proteins leading to the demethylation of previously silenced genes. It has been reported that the anti-cancer drug 5-Azacytidine (5-Aza) mediates the activation of tumor suppressor genes through passive demethylation by inhibiting DNMT1. Our aim was to ascertain, if 5-Aza also induces…
Schlagworte
Demethylation
Tumor
5-Methylcytosine
Diagnosis
Lead
After
Zeitschrift für Gastroenterologie
