Breadth of the HCV-specific CD4+ T cell response in spontaneous resolvers is independent from the IL-28 haplotype
C Scheurich, L Lewis-Ximenez, AW Lohse, RT Chung, AY Kim, GM Lauer, J Schulze zur Wiesch · Zeitschrift für Gastroenterologie · 2015 · Heft 01
Bibliografische Angaben
Zusammenfassung
A minority of patients is able to spontaneously clear an acute hepatitis C virus (HCV) infection. A strong, broad and lasting HCV-specific Th cell response is regarded as a hallmark and best correlate of immunologic control of HCV viremia. On the other hand, it was recently determined that certain polymorphisms (eg. SNP rs12979860) in the region of IL-28B highly correlate with spontaneous resolution of viremia. The aim of this study was to test the hypothesis whether the breadth and priming of HCV CD4+ T cell response is linked to the IL-28 polymorphism. We compare the breadth of the HCV-specific CD4+ T cell res…
