Immune and Inflammatory Cell Composition of Human Lung Cancer Stroma

Recent studies indicate that the abnormal microenvironment of tumors may play a critical role in carcinogenesis, including lung cancer. We comprehensively assessed the number of stromal cells, especially immune/inflammatory cells, in lung cancer and evaluated their infiltration in cancers of different stages, types, and metastatic characteristics. Immunohistochemical analysis of lung cancer tissue arrays containing normal and lung cancer sections was performed. Cells positive for specific markers were counted within whole sections. In human lung cancer sections, we observed a significant elevation/infiltration o…