The Role of Single Nucleotide Polymorphisms in C-type Lectin Receptors for Susceptibility towards Pulmonary Tuberculosis in Hyderabad (India)
TE Klassert, S Goyal, A Hussain, D Driesch, R Binding-Liermann, S Gaddam, V Valluri, N Ahmed, R Schumann, H Slevogt · Pneumologie · 2015 · Heft 02
Bibliografische Angaben
Zusammenfassung
C-type lectin receptors (CTLRs) are a type of Pattern Recognition Receptors (PRRs) expressed in various immune cells that have been newly found to play important role in recognition of Mycobacterium tuberculosis (Mtb). The CTRLs in the Dectin-1 & Dectin-2 clusters on human chromosome 12 are of particular interest. Recently it was found that Mincle & MCL detect mycobacterial cord factor & Dectin-2 directly recognizes the Mannose capped Lipoarabinomannan. Several PRRs have been studied for the role of their SNPs in individual susceptibility to TB. However, no genetic studies have been done in humans for SNPs in th…
