Hydrophobin-Beschichtung zur Okklusionsprävention biliärer Plastikstents – erste Ergebnisse

Fragestellung: Stent occlusion is a major complication in biliary stenting. This porcine study tested a newly developed coated biliary stent with a dedicated new surface proteine (hydrophobin) alone or with hydrophobin and heparin for preventing stent occlusion. Methodik: The stents were placed in into 15 healthy pigs (5 uncoated stents, 5 stents coated with hydrophobin and 5 stents coated with hydrophobin and heparin). After 3 weeks the success rate was evaluated by necropsy and macroscopic and microscopic evaluation (including electron microscopy) of the stents as well as of the bile ducts. The following items…