CareLit Fachartikel
The role of the TGF-β pseudoreceptor Bambi in a mouse model of allergic bronchial asthma
C Vock, M Wegmann, H Fehrenbach · Pneumologie · 2015 · Heft 04
Dokument
1145037
CareLit-ID
Jahr
2015
Publikation
PDF
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Metadaten
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Bibliografische Angaben
Zusammenfassung
Introduction: Allergic bronchial asthma is characterized by chronic inflammation and airway remodeling, which are linked to airway hyperresponsiveness (AHR) and impaired lung function. Transforming Growth Factor beta (TGF-β) is an important anti-inflammatory factor but with persistence of inflammation it mediates structural changes of the airways. Bambi (Bone Morphogenetic Protein and Activin Membrane-bound Inhibitor) was described to act as TGF-β type I pseudoreceptor that lacks the intracellular kinase domain and inhibits TGF-β-dependent signaling. Hence, the current study aimed at investigating the role of Ba…
Schlagworte
Asthma
Cytokines
Cytokine
Airway Remodeling
Goblet Cells
Activin
After
Pneumologie
