Transforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance

Aim: Insulin resistance represents the core component of the so-called Metabolic Syndrome, ultimately promoting glucose intolerance, pancreatic beta cell failure, and overt type 2 diabetes. Based on substantial side effects of existing pharmacological approaches, efficient and safe insulin sensitization and glucose control remain critical therapeutic aims to prevent diabetic late complications. The goal of this study is to characterize the role of Transforming Growth Factor beta-like Stimulated Clone (TSC) 22 D4 protein in insulin resistance and diabetes. Materials and methods: In order to investigate the metabo…