Adaptor protein APPL1 counteracts streptozotocin-induced diabetes in mice

Introduction: The adapter protein APPL1 has been reported for its beneficial role against type 2 diabetes by promoting both secretion and actions of insulin. In this study, we aimed to investigate whether APPL1 plays a protective role in β-cell function in type 1 diabetes Method: Both male 12-week old APPL1 knockout (KO) mice and their wild-type (WT) littermates were treated with 50 mg/kg streptozotocin (STZ) for 5 consecutive days. Fed glucose levels were monitored for 15 days after last injection and glucose tolerance test was performed 5 days after last injection. Pancreases were collected after the mice were…